RDDT Laboratories, RMIT Drug Discovery Technologies Pty Ltd
RDDT Laboratories, a trading division of RMIT Drug Discovery Technologies Pty Ltd is a privately owned GLP compliant preclinical safety and bioanalytical testing company based in Melbourne, Australia.
Since being awarded its GLP accreditation in 2002, RDDT Laboratories’ is equipped to execute a range of toxicology studies (including genotoxicity, acute to chronic repeat dose studies etc) in various mammalian species in accordance to the appropriate regulatory standards. In addition, custom efficacy studies can be validated and performed to meet the clients’ needs. RDDT Laboratories also works closely with a number of partner CROs to provide services in non-mammalian species.
RDDT Laboratories ensures excellent regulatory compliance based on OECD ICH Guidelines in order to deliver the highest quality data to assist clients with their FDA, TGA and other regulatory submissions. RDDT Laboratories’ quality system adheres to OECD and US FDA 21CFR Part 58 GLP requirements.
RDDT Laboratories’ team consists of experienced professionals operating in state-of-the-art laboratory facilities including a new animal house. RDDT Laboratories take enormous pride in the quality of the services they offer, which meet the highest scientific standards, they strive to keep costs low, develop strong and lasting partnerships with all its clients, and ensure the needs of the clients are catered for and completion of the studies to be done in a timely manner.
Number of employees: 20
Main business focus/
Listing by sector:
- Drug Discovery & Development
- Service Provider
- Clinical Trials
- Research Organisation
- A 'one-stop' service to meet all your drug development requirements
- Customised experimental study design for preclinical toxicology and efficacy studies
- Highly skilled management team working closely with qualified scientists
- Good communication with CRO throughout all phases of the program
- A quality framework for all development requirements
- Program management service
- Timely service to meet client's timeframes
- Modern facilities
Preclinical Safety Testing Services GLP Studies: All studies conducted at RDDT Laboratories studies conducted according to GLP principles and OECD guidelines. Depending on the Individual client studies RDDT Laboratories are able to tailor the study to FDA, or TGA or other regulatory requirements.
- AMES Test (Standard Plate Incorporation Assay)
- AMES Test (Liquid Fluctuation Assay)
- Chromosome Aberration Assay
- Micronucleus Test
- MTS Assay- HepG2 + L929 cell lines
- LDH Leakage Assay- HepG2 + L929 cell lines
- L929 Agar diffusion Assay- L929 cell lines
Mammalian Toxicity Studies
- Dose Range Finding Studies
- Acute and Sub-Acute Mammalian Toxicity Studies
- Sub-Chronic and Chronic Mammalian Toxicity Studies
- Skin Sensitisation Studies
- Skin Irritation Studies
RDDT Laboratories’ highly trained staff use an API 4000 Q Trap LC/MS/MS to develop quantitative, validated methods for traditional, small-molecule therapeutics as well as novel biotechnology derived macromolecules. These methods are either developed de novo or implemented from existing procedure.
Pharmacokinetics and toxicokinetics
Pharmacokinetic parameters of the test substance can be determined in both single dose pharmacokinetic studies and repeat dose toxicokinetic studies.
RDDT Laboratories offers custom efficacy studies which can be validated and performed to meet the client’s needs. Working closely with numerous CRO partners, RDDT Laboratories are able to develop and optimize translational efficacy models which are validated with endpoints that are appropriate to our partners’ clinical development plans.
RDDT Laboratories can deliver affordable histology service of the utmost quality. Services include specimen handling, tissue cut-up tissue preparation, embedding, sectioning, haematoxylin and eosin slide preparation and microscopic examination of slides performed by US board certified vert pathologist. With a quality system second to none and our highly qualified staff be certain that RDDT Laboratories will provide you with consistent and reliable results in an efficient manner. Accommodating for both GLP and non- GLP services, their extensive range of capabilities cover all aspects of your histological requirements.
Vitamin D Assay Services
Inaccuracy is something of the past, when dealing with determining Vitamin D metabolites concentrations, using the API 4000 Q Trap LC/MS/MS. With specificity and sensitivity already an advantage, the LC/MS/MS will determine both concentrations of 25-OH Vitamin D2 and 25- OH Vitamin D3 simultaneously, in contrast to other methods used that will only calculate the total Vitamin D concentration. RDDT Laboratories will provide you with fast turn around times and competitive prices for all your Vitamin D testing needs.
Clinical Pathology- clinical biochemistry and haematology investigations are performed in-house
Future preclinical Services at RDDT laboratories
RDDT Laboratories aims to extent their list of services with the addition of Xenograft models from 2009.Initial models will include:
- Breast cancer- MCF-7, MDA-MB231
- Lung Cancer-A549
- Colorectal cancer- HT-29Liver cancer- HepG2
- Cholangiocarcinoma- QBC939
RDDT Laboratories will also endeavour to extend their list of services to develop tumour models.
|Contact person||Dr Frances Guyett|
|Address||PO Box 71|
|Phone||+61 3 9925 7091|
|Fax||+61 3 9925 7020|